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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACLY
All Species:
10.61
Human Site:
T490
Identified Species:
21.21
UniProt:
P53396
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.36
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53396
NP_001087.2
1101
120839
T490
R
S
L
Q
G
K
S
T
T
L
F
S
R
H
T
Chimpanzee
Pan troglodytes
XP_511495
1775
198342
T645
C
L
K
R
G
K
S
T
T
L
F
S
R
H
T
Rhesus Macaque
Macaca mulatta
XP_001108114
1137
124370
G541
P
S
P
R
S
L
Q
G
K
S
T
T
L
F
S
Dog
Lupus familis
XP_850198
1101
120705
A490
R
S
L
Q
G
K
S
A
T
L
F
S
R
H
T
Cat
Felis silvestris
Mouse
Mus musculus
Q91V92
1091
119709
K488
T
L
F
S
R
H
T
K
A
I
V
W
G
M
Q
Rat
Rattus norvegicus
P16638
1100
120617
A489
R
S
L
Q
G
K
S
A
T
L
F
S
R
H
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001025711
1101
121113
T490
R
R
G
A
G
K
A
T
T
L
F
S
R
H
T
Frog
Xenopus laevis
NP_001088452
1101
120767
T490
G
A
A
T
A
K
A
T
T
L
F
T
R
H
T
Zebra Danio
Brachydanio rerio
NP_001002649
1092
119691
K489
T
L
F
S
N
L
T
K
S
I
V
W
G
M
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523755
1112
121387
R502
R
N
G
S
S
L
N
R
K
F
F
S
N
T
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P53585
1106
121598
K498
G
L
F
E
D
D
T
K
A
I
I
W
G
Q
Q
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q8X097
670
72608
H119
V
P
K
A
I
A
K
H
P
D
V
D
V
V
V
Conservation
Percent
Protein Identity:
100
59.9
90.3
98.1
N.A.
97.1
97.5
N.A.
N.A.
93.1
89.3
86.3
N.A.
69.3
N.A.
60.8
N.A.
Protein Similarity:
100
61.1
92.3
99.4
N.A.
98.3
98.6
N.A.
N.A.
96.5
95.3
93
N.A.
81.5
N.A.
76.5
N.A.
P-Site Identity:
100
73.3
6.6
93.3
N.A.
0
93.3
N.A.
N.A.
73.3
53.3
0
N.A.
26.6
N.A.
0
N.A.
P-Site Similarity:
100
80
26.6
93.3
N.A.
13.3
93.3
N.A.
N.A.
80
73.3
20
N.A.
40
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
39.9
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
49.7
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
0
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
9
17
9
9
17
17
17
0
0
0
0
0
0
% A
% Cys:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
9
9
0
0
0
9
0
9
0
0
0
% D
% Glu:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
25
0
0
0
0
0
0
9
59
0
0
9
0
% F
% Gly:
17
0
17
0
42
0
0
9
0
0
0
0
25
0
0
% G
% His:
0
0
0
0
0
9
0
9
0
0
0
0
0
50
0
% H
% Ile:
0
0
0
0
9
0
0
0
0
25
9
0
0
0
0
% I
% Lys:
0
0
17
0
0
50
9
25
17
0
0
0
0
0
0
% K
% Leu:
0
34
25
0
0
25
0
0
0
50
0
0
9
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
17
0
% M
% Asn:
0
9
0
0
9
0
9
0
0
0
0
0
9
0
0
% N
% Pro:
9
9
9
0
0
0
0
0
9
0
0
0
0
0
0
% P
% Gln:
0
0
0
25
0
0
9
0
0
0
0
0
0
9
25
% Q
% Arg:
42
9
0
17
9
0
0
9
0
0
0
0
50
0
0
% R
% Ser:
0
34
0
25
17
0
34
0
9
9
0
50
0
0
9
% S
% Thr:
17
0
0
9
0
0
25
34
50
0
9
17
0
9
59
% T
% Val:
9
0
0
0
0
0
0
0
0
0
25
0
9
9
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
25
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _